I reload rifle ammo, but don't reload shotshell ammo. The reasons follow JJ's explaination.
Shotshells,
I can't come close to reloading quaility nontoxic ammo the way the factories do. Nor are my reloads even close to waterproof, which is the first priority in any shotshell ammo that I purchase now. The factories do a great job in quality and the big retailers use it as "loss-leaders" all the time, so there is no advantage to tinkering forever with the shotshells. Target rounds are also found really cheap if purchased on sale.
Rifles,
I started reloading rifle ammo to satisfy my 30-06, I have yet to find a factory load that it likes. I now use a 180 grain Barnes X "XLC" with 60 grains of IMR 4350 and a CCI 200 primer. I use this round for all my big game hunting and only need to reload for this every other year or so. Mostly due to general shooting of the ammo, I only need a couple a year for game.
I also found great value in reloading varmit rounds for my 22-250. Quality and value, it is also fun!!